In this work, we study English-language vaccine discourse in social media posts, specifically posts on X (formerly Twitter), in seven years before the COVID-19 outbreak (2013 to 2019) and three years after the outbreak was first reported (2020 to 2022). Drawing on theories from social cognition and the stereotype content model in Social Psychology, we analyze how English speakers talk about vaccines on social media to understand the evolving narrative around vaccines in social media posts. To do that, we first introduce a novel dataset comprising 18.7 million curated posts on vaccine discourse from 2013 to 2022. This extensive collection-filtered down from an initial 129 million posts through rigorous preprocessing-captures both pre-COVID and COVID-19 periods, offering valuable insights into the evolution of English-speaking X users' perceptions related to vaccines. Our analysis shows that the COVID-19 pandemic led to complex shifts in X users' sentiment and discourse around vaccines. We observe that negative emotion word usage decreased during the pandemic, with notable rises in usage of surprise, and trust related emotion words. Furthermore, vaccine-related language tended to use more warmth-focused words associated with trustworthiness, along with positive, competence-focused words during the early days of the pandemic, with a marked rise in negative word usage towards the end of the pandemic, possibly reflecting a growing vaccine hesitancy and skepticism.

Both authors contributed equally to this work.

Critical heat flux (CHF) marks the onset of boiling crisis in light-water reactors, defining safe thermal-hydraulic operating limits. To support Phase II of the OECD/NEA AI/ML CHF benchmark, which introduces spatially varying power profiles, this work compiles and digitizes a broad CHF dataset covering both uniform and non-uniform axial heating conditions. Heating profiles were extracted from technical reports, interpolated onto a consistent axial mesh, validated via energy-balance checks, and encoded in machine-readable formats for benchmark compatibility. Classical CHF correlations exhibit substantial errors under uniform heating and degrade markedly when applied to non-uniform profiles, while modern tabular methods offer improved but still imperfect predictions. A neural network trained solely on uniform data performs well in that regime but fails to generalize to spatially varying scenarios, underscoring the need for models that explicitly incorporate axial power distributions. By providing these curated datasets and baseline modeling results, this study lays the groundwork for advanced transfer-learning strategies, rigorous uncertainty quantification, and design-optimization efforts in the next phase of the CHF benchmark.

Capturing the structural changes that molecules undergo during chemical reactions in real space and time is a long-standing dream and an essential prerequisite for understanding and ultimately controlling femtochemistry. A key approach to tackle this challenging task is Coulomb explosion imaging, which benefited decisively from recently emerging high-repetition-rate X-ray free-electron laser sources. With this technique, information on the molecular structure is inferred from the momentum distributions of the ions produced by the rapid Coulomb explosion of molecules. Retrieving molecular structures from these distributions poses a highly non-linear inverse problem that remains unsolved for molecules consisting of more than a few atoms. Here, we address this challenge using a diffusion-based Transformer neural network. We show that the network reconstructs unknown molecular geometries from ion-momentum distributions with a mean absolute error below one Bohr radius, which is half the length of a typical chemical bond.

Natural Language Inference (NLI) models have been used in various ways to improve the factuality of LLM outputs. This is typically done by applying an NLI model to judge whether the model output is entailed from the supposed evidence, triggering some corrective actions, such as beam reranking at inference time or RL rewards during training. While NLI models are trained to detect factual inconsistencies over complete sentences, decisions in the common autoregressive generation architecture are made for each evolving text prefix, during decoding. Addressing this setting, we generalize the entailment detection task to apply over arbitrary text prefixes, and suggest its utility for improving generation faithfulness. Providing suitable evaluation and training datasets for this task, we train MiniTruePrefixes, a novel specialized model that better detects factual inconsistencies over text prefixes, outperforming comparable baseline NLI models by 5-14 F1 points in prefix-level entailment. We further demonstrate that integrating MiniTruePrefixes into a controlled decoding framework substantially improves factual consistency in abstractive summarization. When guided by MiniTruePrefixes, LLaMA-3.2-3B-Instruct matches the faithfulness and runtime of the 8B model from the same model family, while using only half the memory.

Financial narratives from U.S. Securities and Exchange Commission (SEC) filing reports and quarterly earnings call transcripts (ECTs) are very important for investors, auditors, and regulators. However, their length, financial jargon, and nuanced language make fine-grained analysis difficult. Prior sentiment analysis in the financial domain required a large, expensive labeled dataset, making the sentence-level stance towards specific financial targets challenging. In this work, we introduce a sentence-level corpus for stance detection focused on three core financial metrics: debt, earnings per share (EPS), and sales. The sentences were extracted from Form 10-K annual reports and ECTs, and labeled for stance (positive, negative, neutral) using the advanced ChatGPT-o3-pro model under rigorous human validation. Using this corpus, we conduct a systematic evaluation of modern large language models (LLMs) using zero-shot, few-shot, and Chain-of-Thought (CoT) prompting strategies. Our results show that few-shot with CoT prompting performs best compared to supervised baselines, and LLMs' performance varies across the SEC and ECT datasets. Our findings highlight the practical viability of leveraging LLMs for target-specific stance in the financial domain without requiring extensive labeled data.

CNNs are now prevalent as the primary choice for most machine vision problems due to their superior rate of classification and the availability of user-friendly libraries. These networks effortlessly identify and select features in a non-intuitive data-driven manner, making it difficult to determine which features were most influential. That leads to a ``black box", where users cannot know how the image data are analyzed but rely on empirical results. Therefore the decision-making process can be biased by background information that is difficult to detect. Here we discuss examples of such hidden biases and propose techniques for identifying them, methods to distinguish between contextual information and background noise, and explore whether CNNs learn from irrelevant features. One effective approach to identify dataset bias is to classify blank background parts of the images. However, in some situations a blank background in the images is not available, making it more difficult to separate the foreground information from the blank background. Such parts of the image can also be considered contextual learning, not necessarily bias. To overcome this, we propose two approaches that were tested on six different datasets, including natural, synthetic, and hybrid datasets. The first method involves dividing images into smaller, non-overlapping tiles of various sizes, which are then shuffled randomly, making classification more challenging. The second method involves the application of several image transforms, including Fourier, Wavelet transforms, and Median filter, and their combinations. These transforms help recover background noise information used by CNN to classify images. Results indicate that this method can effectively distinguish between contextual information and background noise, and alert on the presence of background noise even without the need to use background information.

The extraction and standardization of pharmacokinetic (PK) information from scientific literature remain significant challenges in computational pharmacology, which limits the reliability of data-driven models in drug development. Large language models (LLMs) have achieved remarkable progress in text understanding and reasoning, yet their adaptation to structured biomedical data, such as PK tables, remains constrained by heterogeneity, noise, and domain shift. To address these limitations, we propose HySim-LLM, a unified mathematical and computational framework that integrates embedding-weighted fine-tuning and manifold-aware denoising to enhance the robustness and interpretability of LLMs. We establish two theoretical results: (1) a similarity-weighted generalization bound that quantifies adaptation performance under embedding divergence, and (2) a manifold-based denoising guarantee that bounds loss contributions from noisy or off-manifold samples. These theorems provide a principled foundation for fine-tuning LLMs in structured biomedical settings. The framework offers a mathematically grounded pathway toward reliable and interpretable LLM adaptation for biomedical and data-intensive scientific domains.

The focus on'food as medicine' is gaining traction in the field of health and several studies conducted in the past few years discussed this aspect of food in the literature. However, very little research has been done on representing the relationship between food and health in a standardized, machine - readable fo rmat using a semantic web that can help us leverage this knowledge effectively. To address this gap, this study aims to create a knowledge graph to link food and health through the knowledge graphs' ability to combine information from various platforms foc using on flavonoid contents of food found in the USDA's databases and cancer connections found in the literature. We looked closely at these relationships using KNARM methodology and represented them in machine - operable format. The proposed knowledge graph serves as an example for researchers, enabling them to explore the complex interplay between dietary choices and disease management. Future work for this study involves expanding the scope of the knowledge graph by capturing nuances, adding more related d ata, and performing inferences on the acquired knowledge to uncover hidden relationships.

The safe use of pharmaceuticals in food-producing animals is vital to protect animal welfare and human food safety. Adverse events (AEs) may signal unexpected pharmacokinetic or toxicokinetic effects, increasing the risk of violative residues in the food chain. This study introduces a predictive framework for classifying outcomes (Death vs. Recovery) using ~1.28 million reports (1987-2025 Q1) from the U.S. FDA's OpenFDA Center for Veterinary Medicine. A preprocessing pipeline merged relational tables and standardized AEs through VeDDRA ontologies. Data were normalized, missing values imputed, and high-cardinality features reduced; physicochemical drug properties were integrated to capture chemical-residue links. We evaluated supervised models, including Random Forest, CatBoost, XGBoost, ExcelFormer, and large language models (Gemma 3-27B, Phi 3-12B). Class imbalance was addressed, such as undersampling and oversampling, with a focus on prioritizing recall for fatal outcomes. Ensemble methods(Voting, Stacking) and CatBoost performed best, achieving precision, recall, and F1-scores of 0.95. Incorporating Average Uncertainty Margin (AUM)-based pseudo-labeling of uncertain cases improved minority-class detection, particularly in ExcelFormer and XGBoost. Interpretability via SHAP identified biologically plausible predictors, including lung, heart, and bronchial disorders, animal demographics, and drug physicochemical properties. These features were strongly linked to fatal outcomes. Overall, the framework shows that combining rigorous data engineering, advanced machine learning, and explainable AI enables accurate, interpretable predictions of veterinary safety outcomes. The approach supports FARAD's mission by enabling early detection of high-risk drug-event profiles, strengthening residue risk assessment, and informing regulatory and clinical decision-making.